Dental Journal of Advance Studies

Ram Rattan Gupta ¹, Manu Gupta ², Shivani Bhickta ¹

Affiliations
1 Department of Periodontology, Bhojia Dental College College & Hospital, Distt. Solan, Himachal Pradesh, IN
2 Punjab, IN

Abstract

In the late 1950's free radicals and antioxidants were almost unheard of in the clinical and biological sciences but chemists had known about them for years in the context of radiation, polymer and combustion technology. Daniel Gilbert, Rebeca Gerschman and their colleagues related the toxic effects of elevated oxygen levels on aerobes to those of ionizing radiation, and proposed that oxygen toxicity is due to free radical formation.

Keywords

Reactive Oxygen Species, Free Radicals, Singlet Oxygen.

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Baljeet Singh ¹, Shivani Bhickta ¹, Rajesh Gupta ¹, Sachin Goyal ¹, Ram Rattan Gupta ¹

Affiliations
1 Department of Periodontology, Bhojia Dental College and Hospital, Distt. Solan, Himachal Pradesh, IN

Abstract

The human inflammatory periodontal diseases are amongst the most common of chronic diseases. The predominant inflammatory cell (96%) within the healthy connective tissue and epithelium of the gingiva is polymorphonuclear leucocyte (PMNL). Periodontopathic bacteria in the gingivomucosal tissue may functionally activate PMNLs leading to an increased production of reactive oxygen species (ROS). Chronic inflammation subjects the nearby cells to elevated levels of free radicals (ROS) due to extracellular release from phagocytic cells. Antioxidants block the process of oxidation by neutralizing free radicals. In doing so, the antioxidant themselves become oxidized. Because of this, there is a constant need to replenish our antioxidant resources.

Keywords

Antioxidants, Periodontal Diseases, Reactive Oxygen Species.

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Ram Rattan Gupta ¹, Manu Gupta ², Avnika Garg ¹

Affiliations
1 Department of Periodontology, Bhojia Dental College and Hospital, Distt. Solan, Himachal Pradesh, IN
2 Punjab, IN

Abstract

In order for periodontal regeneration to occur, progenitor cells must migrate to the denuded ischolar_main surface, attach to it, proliferate and mature into an organized and functional fibrous attachment apparatus. Significant advances have been made during the last decade in understanding the factors controlling the migration, attachment and proliferation of cells. A group of naturally occurring molecules known as polypeptide growth factors in conjunction with certain matrix proteins, are key regulators of these biological events. Of these, the fibroblast growth factors (FGFs) appear to have an important role in periodontal wound healing. The purpose of this review is to summarize current information on these growth factors with emphasis on their potential implications in periodontal wound healing and regeneration.

Keywords

Regeneration, Wound Healing, Fibroblast Growth Factor.

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